Analysis of the Clinical Characteristics of Cutaneous Malignant Tumors: 11-year Single-center Study in Daejeon City and Chungnam Province / 대한피부과학회지

BACKGROUND: The occurrence of cutaneous malignant tumors has been increasing worldwide due to changes in various environmental factors. OBJECTIVE: Our study aimed to analyze the overall tendency of clinical characteristics in single-center patients with cutaneous malignant tumors according to sex, age, duration, size, anatomic site, treatment, and concomitant diseases. METHODS: We retrospectively reviewed the medical records and clinical photographs of 319 patients diagnosed with cutaneous malignant tumors (basal cell carcinoma, squamous cell carcinoma, melanoma, lymphoma, Paget's disease, metastatic skin cancer, mycosis fungoides, angiosarcoma, dermatofibrosarcoma protuberans, Kaposi sarcoma, malignant fibrous histiocytoma, Merkel cell carcinoma) and 109 patients diagnosed with premalignant tumors (Bowen's disease) between January 2007 and January 2017. RESULTS: The average annual incidence of malignant cutaneous tumors was 2.4%. In total, 158 males (36.9%) and 270 females (63.1%) were included with a mean age of onset of 66 years. Among the malignant tumors, basal cell carcinoma (30.8%) was the most common, while the incidences of squamous cell carcinoma (18.9%), melanoma (6.3%), and lymphoma (4.4%) were also high. The predominantly involved anatomic sites were the face (67.3%), trunk (11.5%), and legs (10.9%). Most cases involved solitarily existing tumors (77.3%), and pruritus (21.7%) was the most common accompanying symptom. Among the 69.6% of patients who received treatment for their tumors, the most common method was surgical removal. No significant increase in concomitant diseases or environmental factors was detected. CONCLUSION: Our study is meaningful as an overall and recent review of various types of cutaneous malignancies that provides preliminary data for further large-scale nationwide studies.

A Statistical Study of Cutaneous Malignant Tumors and Premalignant Lesions in Southeastern Gyeonggi-do Province over an 11-year Period (2006~2016) / 대한피부과학회지

BACKGROUND: The incidence of cutaneous malignant tumors and premalignant lesions has recently increased worldwide. However, studies investigating the incidence and clinical manifestations of cutaneous malignant tumors and premalignant lesions in Korea are rare, especially in southeastern Gyeonggi-do Province. OBJECTIVE: To analyze the recent trends in the incidence of cutaneous malignant tumors and premalignant lesions in southeastern Gyeonggi-do Province. METHODS: We retrospectively reviewed 451 cases of cutaneous malignant tumors and 455 cases of premalignant lesions from 2006 to 2016. RESULTS: The average annual incidence rates of cutaneous malignant tumors and premalignant lesions among the total number of outpatients was 0.84% and 0.85%, respectively, and both these rates increased significantly over time. Basal cell carcinoma was most commonly diagnosed cutaneous malignant tumor (50.8%), followed by squamous cell carcinoma (24.6%), malignant melanoma (8.2%), and metastatic carcinoma (5.1%). The most common premalignant lesion was actinic keratosis (60.0%). The mean age of the patients with cutaneous malignant tumors and premalignant lesions was 68.8 years and 70.8 years, respectively. The ratio of male to female patients was 1 : 1.19 for cutaneous malignant tumors and 1 : 2.01 for premalignant lesions. The face was the most common site for both cutaneous malignant tumors and premalignant lesions (at 71.9% and 75.8%, respectively). CONCLUSION: This retrospective study provided data about the incidence and clinical patterns of cutaneous malignant tumors and premalignant lesions among patients in southeastern Gyeonggi-do Province.

A Clinical Investigation of Cutaneous Malignant Tumors in Western Gyeongnam Province over 11 Years / 대한피부과학회지

BACKGROUND: The incidence rates of cutaneous malignant tumors in the Korean population are increasing. However, few clinical studies have been conducted on cutaneous malignant tumors in Gyeongnam Province. OBJECTIVE: The purpose of this study was to evaluate the prevalence of cutaneous malignant tumors in Western Gyeongnam Province and to compare the results with previous reports of cutaneous malignant tumors. METHODS: We retrospectively reviewed 46,277 outpatients who visited the Department of Dermatology from January 2005 to December 2015. Among them, 1,120 patients who underwent biopsy for skin tumors had tumors classified as cutaneous malignant tumors. We compared the histopathological diagnoses and analyzed the distribution of dermatologic diseases and clinical features, including age and sex. RESULTS: The mean age of the patients was 70.0 years. The ratio of male to female patients was 1：1.85. Cutaneous malignant and premalignant tumors were found in 2.4% of all new patients. The most common disease was basal cell carcinoma (39.6%), followed by squamous cell carcinoma (31.5%), malignant lymphoma (6.3%), metastatic carcinoma (5.8%), keratoacanthoma (4.2%), malignant melanoma (4.1%), and extramammary Paget's disease (2.8%). The most common premalignant tumor was actinic keratosis (73.2%), followed by Bowen's disease (26.8%). The most common site of cutaneous malignant tumors and premalignant tumors was the face (75.3% and 80.8%, respectively). CONCLUSION: This study provides useful data on the incidence and characteristics of cutaneous malignant tumors. The frequency of malignant tumors was higher than that found in previous studies.

Clinical Observation of Cutaneous Malignant Tumors and Premalignant Lesions in North-western Gyeonggido Province over 8 Years (2005~2012): A Single Center Study / 대한피부과학회지

BACKGROUND: The incidence of cutaneous malignant tumors and premalignant lesions has continuously increased worldwide. OBJECTIVE: The purpose of this study was to analyze recent changes in the incidence and clinical characteristics of precancerous lesions and cutaneous malignant tumors in North-western Gyeonggido Province and to compare them with other previously reported data. METHODS: We reviewed 107 cases of premalignant lesions and 218 cases of cutaneous malignant tumors out of a total 38,926 new outpatients who had visited the Department of Dermatology at the Ilsan Paik Hospital from January 2005 to December 2012. RESULTS: The average annual incidence of premalignant lesions among the total number of new outpatients was 0.27% and that of cutaneous malignant tumors was 0.56%. The annual incidence of premalignant lesions increased by an average of 1.136 times per year, and that of cutaneous malignant tumors increased by an average of 1.038 times per year for 8 years. The most common premalignant lesion was actinic keratosis (74.77%). Among cutaneous malignant tumors, basal cell carcinoma (42.64%), squamous cell carcinoma (21.32%) and malignant melanoma (8.63%) were common. The mean age of onset was 74.04 years in precancerous lesions and 67.00 years in cutaneous malignant tumors. The most common site for cutaneous malignant tumors was the face (52.75%). The nose (29.57%) was the most preferential site on the face. CONCLUSION: The incidence of premalignant lesions and cutaneous malignant tumors has continuously increased in North-western Gyeonggido Province. Over half of the cases of cutaneous malignancies involved the head and neck area in our studies. Dermatologists need to be aware of clinical presentations of cutaneous malignancies on the head and neck.

A Clinical and Statistical Study of Cutaneous Malignant Tumors in Busan City and the Eastern Gyeongnam Province Over 15 Years (1996~2010) / 대한피부과학회지

BACKGROUND: The incidence of cutaneous malignant tumors, especially basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and malignant melanoma (MM), has continuously increased in Korea. However, there has been little research into the distribution and incidence of malignant skin tumors in the south-eastern part of Korea. OBJECTIVE: The purpose of this study was to analyze recent trends in incidence and clinical patterns of cutaneous malignant tumors in Busan city and the eastern Gyeongnam Province. METHODS: We reviewed 714 cases of cutaneous malignant tumors that include BCC, SCC, and MM from January 1996 to December 2010 at the Department of Dermatology in Dong-A University Hospital. RESULTS: The average annual incidence of cutaneous malignant tumors among the total number of outpatients was 1.18% and has continuously increased from 0.63% to 1.91% over the last 15 years (1996~2010). In particular, the average annual incidence of BCC and SCC has markedly increased from 0.35% and 0.25% to 0.94% and 0.79%, respectively. The most common cutaneous malignant tumor was BCC (48.32%), followed by SCC (41.18%) and MM (10.50%). The mean age of onset in patients who had been diagnosed with cutaneous malignant tumors was 65.07 years (males: 62.04, females: 67.87). There was a similar incidence between males and females in cutaneous malignant tumors (1:1.08). The most common site of cutaneous malignant tumors was the face (66.25%); the cheek (34.04%) was the most preferential site on the face, followed by the nose (30.23%). CONCLUSION: The incidence of cutaneous malignant tumors has gradually increased in Busan city and the eastern Gyeongnam Province, which was relatively higher than the incidence in other areas. It was thought to be due to the higher proportion of the elderly than in other areas of the country and skin cancer centers in our hospital.

A Clinical Observation of Cutaneous Malignant Tumors and Premalignant Lesions in Gangwon Province over 10 Years (1999~2008) / 대한피부과학회지

BACKGROUND: The incidence of cutaneous malignant tumors and premalignant lesions has recently increased according to extended life span, social and medical environment changes. However, a few clinical data have been reported on the survey of cutaneous malignant tumors and premalignant lesions in Gangwon province. OBJECTIVE: To investigate the incidence and clinical patterns of cutaneous malignant tumors and premalignant lesions in Gangwon province. METHODS: We reviewed 485 cases of cutaneous malignant tumors and premalignant lesions from January 1999 to December 2008, at the Department of Dermatology at Wonju Christian Hospital. RESULTS: The average annual incidence of cutaneous malignant tumors among the total number of outpatients was 0.51% and that of premalignant lesions was 0.48%. Both incidences tended to increase with time in 10 year intervals. The most common cutaneous malignant tumor was basal cell carcinoma (47.98%), followed by squamous cell carcinoma (24.19%), extramammary paget's disease (7.26%), metastatic cancer (5.65%), malignant melanoma (4.44%), and lastly, lymphoma (4.44%). Among premalignant lesions, actinic keratosis (74.68%) and Bowen's disease (25.32%) were common. The mean age of onset was 67.53 years in cutaneous malignant tumors and 70.51 years in premalignant lesioins. The most common site for both, the cutaneous malignant tumors and premalignant tumors, was the face (63.97% and 81.43%, respectively). The ratio of men to women was 1.11:1 in cutaneous malignant tumors and 1:2.48 in premalignant lesions. CONCLUSION: The incidence of cutaneous malignant tumors and premalignant lesions has gradually increased in Gangwon province. This data will be made available for the study about the association of cutaneous malignant tumors and premalignant lesions.

A Statistical Survey of Major Cutaneous Malignant Tumors for the Last 10 Years (2000~2010, North-east Gyeonggido Province) / 대한피부과학회지

BACKGROUND: Major cutaneous malignant tumors (MCMT) including squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and malignant melanoma (MM) result from multifactorial causes such as environmental and host factors. In particular, ultraviolet radiation (UVR) comprised of environmental factors is estimated to be one of the most important risk factors for MCMT. OBJECTIVE: The purpose of this study was to analyze recent changes in the incidence of MCMT in patients from the north-east area of gyeonggido, and compare that incidence with data previously reported. METHODS: We retrospectively reviewed the medical records of 212 patients diagnosed as MCMT at the Department of Dermatology at the Uijeongbu St. Mary's Hospital during the last 10 years. RESULTS: The average annual incidence of MCMT was 0.3% and it seemed to increase. Among the 212 cases of malignant tumors, the most common malignant tumor was BCC (62.7%). The incidence of SCC and MM were 25% and 12.3%, respectively. The mean age of patients was 68.4+/-14.15 years for those with MCMT; 66.8 y in BCC, 74.5 y in SCC and 64.5 y in MM. The ratio of men to women was 0.72:1. Compared with the incidence of MCMT in other provinces, the north-east portion of Gyeonggido (0.3%) had a high incidence of MCMT. CONCLUSION: High altitude may increase the amount of UVR exposure and influence the development of cutaneous malignant tumors. Individual behaviors including outdoor activity and use of sun blocks are important to the development of major cutaneous tumors and should not be ignored.

A Statistical Observation on 1,430 Cases of Cutaneous Malignant Tumors over 20 Years (1987~2006) in Gwangju City and Chonnam Province / 대한피부과학회지

BACKGROUND: The incidence of cutaneous malignant tumors has recently markedly increased due to the increased longevity of life, along with the changes of social and environmental factors. However, few articles have reported on these changes, from a statistical aspect, of malignant skin tumors in Gwangju City and Chonnam Province. OBJECTIVE: Our purpose was to clarify the recent trends and changes in the incidence and clinical patterns of cutaneous malignant tumors observed in Gwangju City and Chonnam Province and to compare them with the previously reported data. METHODS: A total of 1,430 cases were pathologically diagnosed as cutaneous malignant tumor during a 20 year period between January 1987 and December 2006 at the Department of Dermatology in Chonnam National University Hospital. The tumor incidence and its changes, the age and gender distribution and the anatomical sites were investigated. RESULTS: The average annual incidence of cutaneous malignant tumors among the total number of outpatients was 1.4+/-0.5%. The incidence of cutaneous malignant tumors increased with time in 10-year intervals, from 1+/-0.25% (1987~1996) to 1.83+/-0.38% (1997~2006). Among the malignant tumors, the incidence of basal cell carcinoma (BCC) was increased up to 1.14% (1997~2006) as compared to 0.05% (1987~1996). The most common tumor among the 1,430 patients with cutaneous malignant tumor was BCC (58.96%), followed by squamous cell carcinoma (SCC) (17.58%), malignant melanoma (MM) (10.01%), metastatic carcinoma (3.57%) and malignant lymphoma (3.01%). The mean age of onset of the patients who were diagnosed with cutaneous malignant tumors was 63.64 years old (males: 62.23, females: 63.61) in this study. There was a similar incidence of malignant skin tumors between the males and females (1:1.04). The most common site for the development of malignant skin tumors were the head and neck where 94.54% of the BCCs and 63.3% of SCCs developed. The nose (33.02%) was the most preferential site for BCC, followed by the cheek (20.72%). SCC most frequently developed in the cheek (20.72%), followed by the lower lip (10.76%). The most frequent site for the development of MM was the sole and heel (36.37%) rather than the head and neck (14.7%). CONCLUSION: The total number of patients and the incidence of malignant skin tumors have gradually increased in the area of Gwangju City and Chonnam Province. Especially, BCC has markedly increased and this is mainly due to the increment of aged people in this area, along withsocial and environmental factors.

A 10 Year Period ( 1984 - 1993 ) of Clinical Observation of Cutaneous Malignant Tumors / 대한피부과학회지

BACKGROUND: Skin cancers arc the most common malignancies in human. The increasing incidence of skin cancer has been attributed to increasing exposure of the papulation to sunlight and other factors, such as chemicals or. viruses. OBJECTIVE: The purpose of this study is to investigate a recent 10 year period(1984-1993) of clinical observation of cutaneous malignant tumors. METHODS: A statistical study was made with 60 cases of malignant tumors that visited the Departrnent of Dermatology, Chung Ang University during a 10 year period(1984-1993). RESULTS: 1. The mean incidence of cutlneous malignant tumors in the total number of outpatients was 0.16%(60/36,416). The incidence of malignant turnors has tended to increase in the last 4 years. 2. The age of onset was quite varied but the majority of cases, 51 cases(85.0%), were over 40 years old. The ratio of rnen to women was 1.3: 1.3. Among the 60 cases of malignant cutaneous tumors, the most frequently observed tumor was basal cell carcinoma, 20 cases(33.3% ). The next most frequent tumors were squamous cell carcinoma, 9 cases(15.0%), metastatic carcinoma, 9 cases(15.0%) and malignant melanoma, 6 cases(10.0%). 4. Among the 20 cases of basal cell carcinoma, 19 cases(95.0%) were over 40 years old. The most frequent age was the 7th decade(30.0%). The most common predilection sites were the nose (30.0%), the cheek(20.0%) and the eyelid(10.0%). 5. Among the 9 cases of squamous cell carcinoma, 8 cases(88.9% ) were over 40 years old. The ratio of men to women was 1: 2. The most frequent age was the 8th decade(44.4% ). The most common predilection sites were the head(55.6%), lower extremity(22.2%), upper extremity (11.1%) and trunk(11.1%). 6. All patients with malignant melanoma were over 40 years old. The most frequent age was the 5th decade(50.0%). The most cornmon predilection sites were the upper and lower extremities (66.7% ). 7. Among the 9 cases of metastatic carcinoma, 7 cases(77.8%) were over 40 years old. The ratio of men to women was 1: 1.25. The most frequent primary tumor was stomach cancer in men and lung cancer in women. 8. Cutaneous malignant tumor. usually had no detectable metastasis but there were 2 cases of extramammary Pagets disease with metastasis in the regional lymph nodes. CONCLUSIONS : This study revealed that the incidence of malignant tumors has tended to increase over the last few years, the most frequent age was over 40 years old, the most observed turnor was basal cell carcinoma and any type of cutaneous malignant tumors was rarely metastasis.